Comparison between hypertonic saline and mannitol in the reduction of elevated intracranial pressure in a rodent model of acute cerebral injury.

مقایسه اثر سرم مانیتول 20 درصد با سالین هیپرتونیک 5 درصد در درمان استروک مغزی (کارآزمایی بالینی دوسوکور)

  Introduction : Various treatments are used to reduce cerebral edema in stroke patients that show signs of RICP. Mannitol is used as the first line of standard therapy in the control of RICP in the acute phase. Presently most of the researches are focused on the use of hypertonic saline in the treatment of cerebral edema and recent studies have shown that it can replace serum mannitol and may ...

Clinical Studies Effects of 23.4% Sodium Chloride Solution in Reducing Intracranial Pressure in Patients with Traumatic Brain Injury: a Preliminary Study

Accepted, April 28, 2005. OBJECTIVE: Mannitol is the standard of care for patients with increased intracranial pressure (ICP), but multiple administrations of mannitol risk renal toxicity and fluid accumulation in the brain parenchyma with consequent worsening of cerebral edema. This preliminary study assessed the safety and efficacy of small-volume injections of 23.4% sodium chloride solution ...

Mannitol Vs Hypertonic Saline in the Treatment of Increased Intracranial Pressure in Traumatic Brain Injury Patients Authors

1* Associate Professor, Dept of Neurosurgery, Mamata Medical College, Khammam, Telangana 2 Assistant Professor, Dept of Neurosurgery, Sidhartha Medical College, Vijayawada, Andhra Pradesh *Corresponding Author Jagadeesh Babu. K Associate Professor, Department of Neurosurgery, Mamata Medical College, Khammam, Telangana, Email: [email protected], Phone no: 8374590275 Abstract Medical mana...

Comparison of Equimolar Doses of Mannitol and Hypertonic Saline for the Treatment of Elevated Intracranial Pressure After Traumatic Brain Injury: A Systematic Review and Meta-Analysis: Erratum

Hypertonic saline more efficacious than mannitol in lethal intracranial hypertension model.

BACKGROUND Medical management of brain edema and elevated intracranial pressure (ICP) is a crucial challenge in neurosurgical practice. Depending on the cause, the treatments for brain edema fall into three categories: stabilization of the blood-brain barrier, depletion of brain water and surgical decompression. Although mannitol is the mainstay of hyperosmolar therapy, hypertonic saline (HS) i...